Table 5 Clinical trials carried out on Taiwanofungus camphoratus, Inonotus obliquus, and Tropicoporus linteus
Intervention | Dosage form | Subject recruitment | Clinical Outcome | Reference |
|---|---|---|---|---|
T. camphorata | 420 mg three capsules per day | 41 patients have systolic blood pressure between 130 and 179 mmHg or diastolic blood pressure between 85 and 109 mmHg | Decrease in both systolic and diastolic blood pressure among individuals in the TC mycelium group and risk of cardiovascular disease, likely influenced by the inhibition of renin secretion and modulation of the renin-angiotensin system | |
Golden-T. camphorata | 300 mg tablets daily | 80 participants with elevated γ-glutamyl transferase levels | Decline in serum ALT and AST levels, as well as reduced levels of triglycerides in patients, exhibited hepatoprotective effects | Yen et al. [248] |
T. camphorata | Routine chemotherapy regimens with 20 mL, twice a day | 37 advanced cancer patients | No significant benefit on fatigue or quality of life related outcomes | Tsai et al. [249] |
I. obliquus | 1 tablespoon, 3 times/day, 20–30 min before meals | 50 patients with psoriasis | 92% reduction of Complete psoriatic eruptions. Gastrointestinal tract symptoms were modified or disappeared completely | Dosychev and Bystrova [250] |
I. obliquus | 4.5 ml/day, 45 ml/day, 90 ml/day in each respective groups | 58 patients with peptic ulcers | Temporary reduction in pain, and higher doses results in a greater decrease in pain | Fedotov and Yu [251] |
T. linteus | 1,000 mg/day and 1,500 mg/day daily in each respective groups | 30 participants with a history of upper respiratory infections | Has immune-enhancing potential, and showed anti-inflammatory properties | Ku and Kang [252] |
T. linteus | 1,000 mg/day and 2000 mg/day daily in each respective groups | 24 patients having knee osteoarthritis for 6 months or long | Relieves pain from knee arthritis and reduce markers of inflammation | Ryu, Lee, and Kang [253] |
T. linteus | 1100 mg 3 times per day orally | 323 pancreatectomy patients | Enhances adherence to chemotherapy after curative resection, reduces chemotherapy-related toxicities, and improves survival rates | Sung Hwan Lee et al. [254] |